研究队伍
姓名: 陈佳 性别:
学科类别: 分析化学 职务:
学历: 博士研究生 职称: 副研究员
电话: 0931-4968270 传真: 0931-4968019
电子邮件: jiachen@licp.cas.cn
通讯地址: 甘肃省兰州市城关区天水中路18号

简  历:

中国科学院兰州化学物理研究所,副研究员,硕士生导师

2020.8~至今 中国科学院兰州化学物理研究所 (甘肃省天然药物重点实验室,中科院西北特色植物资源化学重点实验室) 副研究员

2015.8~2020.8 中国科学院兰州化学物理研究所 (甘肃省天然药物重点实验室,中科院西北特色植物资源化学重点实验室) 助理研究员

2013.7~2015.8 中国科学院兰州化学物理研究所 (甘肃省天然药物重点实验室,中科院西北特色植物资源化学重点实验室) 研究实习员

陈佳,中共党员,2013年7月进入中国科学院兰州化学物理研究所工作(期间获博士学位),现任副研究员,2021年入选中国科学院青年创新促进会会员。主要从事纳米材料在生物标志物检测与药物分离方面的应用基础研究工作。在纳米材料制备、探针构建、光学传感、分离分析等方面积累有丰富的研究经验。作为项目负责人,先后主持国家自然科学基金在内的科研项目7项。作为项目骨干,参与中国科学院“百人计划”A类项目、中国科学院“一三五”重点培育项目、科技部重点研发项目“固废专项”、国家自然科学基金等多项基金项目。近年来,已在Anal. Chem., Chem. Commun., Biosens. Bioelectron., Sens. Actuators B Chem., TrAC Trends Anal. Chem., J. Chromatogr. A, J. Mater. Chem. B等国内外同行认可的重要学术期刊上发表论文80余篇,他引1700余次,申请国家发明专利22项。2020~2021连续两年获Chinese Chemical Letters优秀审稿人,现任《Journal of Analysis and Testing》首届青年编委,中国分析测试协会青年学术委员会委员。

研究方向:

主要围绕纳米材料在生物标志物检测与药物分离中的关键科学与技术问题,开展分析化学与生物医学和纳米技术等交叉应用基础研究工作,包括:

1. 纳米光学传感体系的构筑及应用;

2. 纳米酶的设计合成、传感分析及抗菌研究;

3. 色谱分离新材料。

获奖及荣誉:

承担科研项目:

1. 中国科学院青年创新促进会:化学材料组,人才项目(2021.12024.12,在研,会员证编号:2021420

2. 中国科学院修缮购置专项:兰州化物所功能分子生物色谱分离分析平台建设 (2021.12021.12,在研,主持)

3. 甘肃省自然基金-一般项目:“激活性”多功能球形共价有机框架纳米载药体系的精准构筑及性能研究 (2021.22023.1,在研,主持)

4. 兰州化物所青年科技工作者协同创新联盟合作基金:碳基多孔复合催化材料光催化降解抗生素的研究 (2020.62022.5,在研,共同主持)

5. 城关区科技计划项目(技术创新类):黄芪活性成分绿色提取及高效分离 (2020.62022.5,在研,主持)

6. 国家自然科学基金青年科学基金项目:基于功能化核酸的非标记光学传感新方法及其在超痕量肿瘤标志物检测中的应用研究 (2015.12017.12,已结题,主持)

7. 甘肃省青年科技基金:基于功能化核酸和工具酶信号放大的非标记超灵敏光学传感新方法研究(2014.72016.6,已结题,主持)

代表论著:

1.     Guoying Luo#, Lanlan Sun#, Heng Li,Jia Chen*, Peilan He, Liang Zhao, Wei Tang*, Hongdeng Qiu, The potent radioprotective agents: Novel nitronyl nitroxide radical spin-labeled resveratrol derivatives, Fitoterapia, 2021, 155, 105053.

2.      Yu Wang, Jia Chen*, Ming Guan*, Hongdeng Qiu*, Preparation of Fe/Ni bimetallic oxide porous graphene composite materials for efficient adsorption and removal of sulfonamides, Langmuir, 2021, DOI: 10.1021/acs.langmuir.1c02275.

3.      Yu Wang, Jia Chen*, Hirotaka Ihara, Ming Guan*, Hongdeng Qiu*, Preparation of porous carbon nanomaterials and their application in sample preparation: A review, TrAC Trends in Analytical Chemistry, 2021, 143, 116421.

4.      Danni Jiang, Jia Chen*, Ming Guan, Hongdeng Qiu*, Octadecylimidazolium ionic liquids-functionalized carbon dots and their precursor co-immobilized silica as hydrophobic chromatographic stationary phase with enhanced shape selectivity, Talanta, 2021, 233, 122513.

5.      Jia Chen, Ning Yuan, Danni Jiang, Qian Lei, Bei Liu, Weiyang Tang, Kyung Ho Row*, Hongdeng Qiu*, Octadecylamine and glucose-coderived hydrophobic carbon dots-modified porous silica for chromatographic separation, Chinese Chemical Letter, 2021, DOI: 10.1016/j.cclet.2021.04.052.

6.      Jean Claude Munyemana, Jia Chen*, Hao Tang, Yangxia Han, Juanjuan Wang, Hongdeng Qiu*, Discriminative detection of dopamine and tyrosinase based on polydopamine dots triggered by fenton-like activity of Mn3O4 nanoparticles, ACS Applied Nano Materials, 2021, 4, 2820.

7.      Jean Claude Munyemana, Jia Chen*, Yangxia Han, Shusheng Zhang, Hongdeng Qiu*, A review on optical sensors based on layered double hydroxides nanoplatforms, Microchimica Acta, 2021, 188: 80.

8.      Jia Chen, Zhengjun Gong*, Weiyang Tang, Kyung Ho Row*, Hongdeng Qiu*, Carbon dots in sample preparation and chromatographic separation: Recent advances and future prospects, TrAC Trends in Analytical Chemistry, 2021, 134: 116135.

9.      Jia Chen#, Xin Wei#, Hao Tang, Jean Claude Munyemana, Ming Guan, Shusheng Zhang, Hongdeng Qiu*, Deep eutectic solvents-assisted synthesis of ZnCo2O4 nanosheets as peroxidase-like nanozyme and its application in colorimetric logic gate, Talanta, 2021, 222: 121680.

10.   Jia Chen, Hongdeng Qiu, Shulin Zhao*, Fabrication of chemiluminescence resonance energy transfer platform based on nanomaterial and its application in optical sensing, biological imaging and photodynamic therapy, TrACTrends in Analytical Chemistry, 2020, 122: 115747.

11.   Jia Chen, Xin Wei, Hao Tang, Mohammad Chand Ali*, Yangxia Han, Zhan Li, Hongdeng Qiu*, Highly discriminative fluorometric sensor based on luminescent covalent organic nanospheres for tyrosinase activity monitoring and inhibitor screening, Sensors and Actuators: B. Chemical, 2020, 305: 127386.

12.   Jean Claude Munyemana, Jia Chen*, Xin Wei, Mohammad Chand Ali, Yangxia Han, Hongdeng Qiu*, Deep eutectic solvents-assisted facile synthesis of copper hydroxide nitrate nanosheets as recyclable enzyme-mimicking colorimetric sensor of biothiols, Analytical and Bioanalytical Chemistry, 2020, 412: 4629.

13.   Yangxia Han, Jia Chen*, Zhan Li, Hongli Chen, Hongdeng Qiu*, Recent progress and prospects of alkaline phosphatase biosensor based on fluorescence strategy, Biosensors and Bioelectronics, 2020, 148: 111811.

14.   Ning Yuan, Jia Chen*, Hang Zhou, Mohammad Chand Ali, Ming Guan, Hongdeng Qiu*, Nitrogen-doping to enhance the separation selectivity of glucose-based carbon dots-modified silica stationary phase for hydrophilic interaction chromatography, Talanta, 2020, 218: 121140.

15.  Xin Wei,Jia Chen*, Mohammad Chand Ali, Jean Claude Munyemana, Ming Guan, Hongdeng Qiu*, Cadmium cobaltite nanosheets synthesized in basic deep eutectic solvents with oxidase-like, peroxidase-like and catalase-like activities and application in colorimetric assay of glucose, Microchimica Acta, 2020, 187: 314.

16.   Ning Yuan, Jia Chen*, Tianpei Cai, Zhan Li, Ming Guan, Liang Zhao, Hongdeng Qiu*, Glucose-based carbon dots-modified silica stationary phase for hydrophilic interaction chromatography, Journal of Chromatography A, 2020, 1619: 460930.

17.   Jia Chen#, Yanni Huang#, Xin Wei, Xiaoqiang Lei, Liang Zhao, Ming Guan, Hongdeng Qiu*, Covalent organic nanospheres: facile preparation and application in high-resolution gas chromatographic separation, Chemical Communications, 2019, 55: 10908-10911.

18.   Jia Chen, Li Wang, Yanni Huang, Zhan Li, Haijuan Zhang, Mohammad Chand Ali, Juewen Liu*, Xingguo Chen, Hongdeng Qiu*, Fabrication of nanoporous graphene/cuprous oxide nanocomposite and its application for chemiluminescence sensing of NADH in human serum and cells, Sensors and Actuators: B. Chemical, 2019, 290: 15-22.

19.   Jia Chen, Yunchun Li, Yanni Huang, Haijuan Zhang, Xingguo Chen, Hongdeng Qiu*, Fluorometric dopamine assay based on an energy transfer system composed of aptamer-functionalized MoS2 quantum dots and MoS2 nanosheets, Microchimica Acta, 2019, 186: 58.

20.   Haijuan Zhang#, Jia Chen#, Yali Yang, Li Wang, Zhan Li, Hongdeng Qiu*, Discriminative detection of glutathione in cell lysates based on oxidase-like activity of magnetic nanoporous graphene, Analytical Chemistry, 2019, 91: 5004-5010.

21.   Mohammad Chand Ali, Jia Chen*, Haijuan Zhang, Zhan Li, Liang Zhao, Hongdeng Qiu*, Effective extraction of flavonoids from Lycium barbarum L. fruits by deep eutectic solvents-based ultrasound-assisted extraction, Talanta, 2019, 203: 16-22.

22.   Zerong Long, Shilin Shen, Yi Lu, Wei Lan, Jia Chen*, Hongdegn Qiu*, Monodisperse core-shell-structured SiO2@Gd2O3:Eu3+@SiO2@MIP nanospheres for specific identification and fluorescent determination of carbaryl in green tea, Analytical and Bioanalytical Chemistry, 2019, 411: 4221-4229.

23.   Jia Chen, Juewen Liu, Xingguo Chen, Hongdeng Qiu*, Recent progress in nanomaterial-enhanced fluorescence polarization/anisotropy sensors, Chinese Chemical Letters, 2019, 30: 1575-1580.

24.  Jia Chen, Mohammad Chand Ali*, Ruirui Liu, Munyemana Jean Claude, Zhan Li, Honglin Zhai, Hongdeng Qiu*, Basic deep eutectic solvents as reactant, template and solvents for ultra-fast preparation of transition metal oxide nanomaterials, Chinese Chemical Letters, 2020, 31: 1584-1587.

25.   Mei Li, Jia Chen*, Jiaping Pan, Zuliang Huang, Hongdeng Qiu*, Facile and sensitive S1 endonuclease activity and inhibition assay using positively-charged Ag nanorods, Chinese Chemical Letters, 2019, 30: 541-544.

26.   Yanni Huang, Jia Chen*, Zhan Li, Li Wang, Ming Guan, Hongdeng Qiu*, Porous graphene-coated stainless-steel fiber for direct immersion solid-phase microextraction of polycyclic aromatic hydrocarbons, Analytical Methods, 2019, 11: 213-218.

27.   Wei Xin, Chen Jia*, Guan MingQiu Hongdeng*, Application of covalent organic frameworks in chromatographic separation, optical sensing and sample pretreatment, Chinese Journal of Analytical Chemistry, 2019, 47: 1721-1713.

28.   Jia Chen, Yanni Huang, Xiaoyan Yang, Haijuan Zhang, Zhan Li, Bo Qin, Xingguo Chen, Hongdeng Qiu*, Highly sensitive and visual detection of guanosine 3-diphosphate-5-di(tri)phosphate (ppGpp) in bacteria based on copper ions-mediated 4-mercaptobenzoic acid modified gold nanoparticles, Analytica Chimica Acta, 2018, 1023: 89-95.

29.   Jia Chen, Qiao Chen, Junying Chen, Hongdeng Qiu*, Magnetic carbon nitride nanocomposites as enhanced peroxidase mimetics for use in colorimetric bioassays, and their application to the determination of H2O2 and glucose, Microchimica Acta, 2016, 183: 3191-3199.

30.   Jia Chen, Cunji Gao, Abul K. Malik, Hongdeng Qiu*, A WS2 nanosheet-based nanosensor for the ultrasensitive detection of small molecule–protein interaction via terminal protection of small molecule-linked DNA and Nt.BstNBI-assisted recycling amplification, Journal of Materials Chemistry B, 2016, 4:5161-5166.

31.   Jia Chen, Hongdeng Qiu*, Mingliang Zhang, Tongnian Gu, Shijun Shao, Yong Huang, Shulin Zhao, Hairpin assembly-triggered cyclic activation of DNA machine for label-free and ultrasensitive chemiluminescence detection of DNA, Biosensors and Bioelectronics, 2015, 68: 550-555.

32.   Jia Chen, Qiao Chen, Cunji Gao, Mingliang Zhang, Bo Qin, Hongdeng Qiu*, A SiO2 NP–DNA/silver nanocluster sandwich structure-enhanced fluorescence polarization biosensor for amplified detection of hepatitis B virus DNA, Journal of Materials Chemistry B, 2015, 3: 964-967.

33.   Jia Chen, Yong Huang, Marina. Vdovenko, Ivan Yu. Sakharov, Guifa Su, Shulin Zhao*, An enhanced chemiluminescence resonance energy transfer system based on target recycling G-guadruplexes/hemin DNAzyme catalysis and its application in ultrasensitive detection of DNA, Talanta, 2015, 138: 59-63.

34.   Jia Chen, Yunyun Guo, Qiao Chen, Hongdeng Qiu*, Sensitive and selective DNA detection based on lambda exonuclease assisted signal amplification, Chinese Journal of Analytical Chemistry, 2015, 43: 1513-1519.

35.   Yong Huang#, Jia Chen#, Shulin Zhao*, Ming Shi, Zhen Feng Chen, Hong Liang*, Label-free colorimetric aptasensor based on nicking enzyme assisted signal amplification and DNAzyme amplification for highly sensitive detection of protein, Analytical Chemistry, 2013, 85: 4423-4430.

36.   Jia Chen#, Yong Huang#, Ming Shi, Shulin Zhao*, Yanchun Zhao, Highly sensitive multiplexed DNA detection using multi-walled carbon nanotube-based multicolor nanobeacon, Talanta, 2013, 109: 160-166.

37.   Jia Chen, Yong Huang, Shulin Zhao*, Xin Lu, Jianniao Tian, Gold nanoparticles-based fluorescence resonance energy transfer for competitive immunoassay of biomolecules, Analyst, 2012, 137: 5885-5890.

38.   蒋丹妮,陈佳*,关明,邱洪灯*,手性纳米材料的制备及在生物传感中的应用, 分析试验室2020, 39: 65-78.

39.   远宁, 陈佳*, 关明, 赵亮, 邱洪灯*, 碳点在样品前处理及色谱分离中的应用, 色谱, 2020, 38: 36-40.

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